[Research] Long-term efficacy and adverse effects of cannabidiol in adjuvant treatment of drug-resistant epilepsy: a systematic review and meta-analysis

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Bernard

Bernard

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Results: Fifty studies were included in this systematic review. A total of 4791 participants were collected. ... Subgroup analyses showed that there was no significant difference on efficacy and safety among age subgroups and epilepsy syndromes subgroups. For most periods, there were no significant difference on efficacy among subgroups of dose and concomitant ASMs. However, higher doses and more concomitant ASMs were associated with higher proportion of adverse events.

Conclusion: Cannabidiol treatment of DRE has stable efficacy and fewer adverse events in early period. Long-term use may have decreased efficacy and increased adverse events. Dose escalation may not increase efficacy, but may increase adverse events. Furthermore, cannabidiol use may reduce dosage of other ASMs without reducing efficacy, thereby reducing adverse effects. Cannabidiol may have similar effects in various epilepsy syndromes.
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pubmed.ncbi.nlm.nih.gov

Long-term efficacy and adverse effects of cannabidiol in adjuvant treatment of drug-resistant epilepsy: a systematic review and meta-analysis - PubMed

PROSPERO (CRD42022351250).
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

Commercially available CBD oils can vary wildly in quality, but I would have to think that folks participating in studies would be using a CBD oil with higher quality control and standardized formulations. The conclusion seems to indicate that CBD oil is not a good long term option. :(
 
I see it's been a while since you've posted, but I'm curious—has anyone tried switching between CBD isolate and full-spectrum CBD and noticed a difference in seizure control or side effects? I’ve been reading mixed things online, and it seems like some people respond much better to one than the other. Would love to hear how that’s played out for anyone here.
 
I've been using CBD oil along with my seizure meds for years and the seizures decreased a lot but then I started
taking apple cider vinegar with mother in it which is a good bacteria and a good protein. I was doing this to lose
weight and my seizures decreased even more so I cut out the CBD and the seizures are still very low.
I wish all of you only the best and May God Bless You!

Sue
 
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