Epilepsy News

Caregiver-Reported Epilepsy Management in Juvenile-Onset Huntington Disease - CONCLUSIONS: Despite advances in epilepsy management, older medications requiring lab monitoring and with greater side effect risks continue to be used most often in JHD. Long-term video EEG modalities were used, which for patients with JHD, can be informative for differentiating movement disorder from seizure. Future prospective longitudinal natural history studies of epilepsy in JHD will be n...

Systematic statistical analysis of change in SEIzure interVAL with diazepam nasal spray supports this novel clinical endpoint for immediate-use seizure medication - OBJECTIVE: Appropriate endpoints for daily antiseizure medications may differ from those for intermittent, immediate-use seizure medications (ISMs). The observed interval between seizure clusters over time (SEIzure interVAL [SEIVAL]) has been proposed as a novel effectiveness endpoint for ISMs. SEIVAL was initially identified pragmatically. This post hoc analysis evaluated how the study timelin...

Effectiveness of adjunctive low-dose clobazam in adults with focal drug-resistant epilepsy and incomplete response to cenobamate: A real-world study - OBJECTIVE: Cenobamate (CNB) is a highly effective antiseizure medication (ASM) for focal drug-resistant epilepsy (DRE); nevertheless, even with CNB treatment and optimized therapy, a substantial proportion of patients continued to experience seizures. Preliminary observations suggest that clobazam (CLB), a 1,5-benzodiazepine, may enhance CNB efficacy. We aimed to evaluate the real-world effecti...

The role of China's acute seizure action plan in the management of out-of-hospital seizures in children with epilepsy: a pilot study - INTRODUCTION: This study aimed to explore the function and applicability of localized China acute seizure action plan (CASAP) in the management of out-of-hospital seizures in children with epilepsy, and to provide a theoretical basis and practical framework for further optimisation and promotion of this action plan.

Elucidating the putative role of cannabigerol: a hypothesis-generating review of neuroinflammatory and neuroprotective mechanisms with implications for drug-resistant epilepsy - Drug-resistant epilepsy (DRE) affects approximately 30% of individuals with epilepsy and remains a major clinical challenge despite the availability of multiple antiseizure medications (ASMs). Beyond recurrent seizures, accumulating evidence implicates chronic neuroinflammation, blood-brain barrier (BBB) dysfunction, excitotoxic injury, and progressive neurodegeneration as processes associated ...

Headache comorbidity in epilepsy and functional/dissociative seizures: an exploratory cross-sectional study in a tertiary epilepsy center - INTRODUCTION: Headache disorders are common in patients with epilepsy and functional/dissociative seizures (FDS) and may influence quality of life and clinical outcomes. Migraine has been proposed as a reciprocal risk factor for epileptic and functional seizures. We aimed to determine the prevalence of headache disorders and associated clinical factors in a cohort of patients undergoing video-E...

Brain signal irregularity may provide clues to understanding epileptic process - Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.

Breakthrough tech enables seizure localization in minutes - New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.

Antidepressant use during pregnancy not linked to epilepsy in children - A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.